Authors: Yuyu Guo, Lei Bi, Euijoon Ahn, Dagan Feng, Qian Wang, Jinman Kim Description: Dynamic medical images are often limited in its application due to the large radiation doses and longer image scanning and reconstruction times. Existing methods attempt to reduce the volume samples in the dynamic sequence by interpolating the volumes between the acquired samples. However, these methods are limited to either 2D images and/or are unable to support large but periodic variations in the functional motion between the image volume samples. In this paper, we present a spatiotemporal volumetric interpolation network (SVIN) designed for 4D dynamic medical images. SVIN introduces dual networks: the first is the spatiotemporal motion network that leverages the 3D convolutional neural network (CNN) for unsupervised parametric volumetric registration to derive spatiotemporal motion field from a pair of image volumes. the second is the sequential volumetric interpolation network, which uses the derived motion field to interpolate image volumes, together with a new regression-based module to characterize the periodic motion cycles in functional organ structures. We also introduce an adaptive multi-scale architecture to capture the volumetric large anatomy motions. Experimental results demonstrated that our SVIN outperformed state-of-the-art temporal medical interpolation methods and natural video interpolation method that has been extended to support volumetric images. Code is available at .