Abstract: Magnetic resonance imaging with hyperpolarized contrast agents can provide unprecedented in vivo measurements of metabolism, but yields images that are lower resolution than that achieved when imaging water. To simultaneously display both images to the user, perhaps by fusing the images together, one must first interpolate the metabolic image to be the same size as that of the proton image. Common choices for doing so include nearest-neighbor interpolation and linear interpolation. In this work, we present a method that uses the proton imagery to inform the interpolation values of the metabolic image. The interpolated image is the result of a convex optimization algorithm which is solved with the Fast Iterative Shrinkage Threshold Algorithm (FISTA). Results are shown with imagery of hyperpolarized pyruvate from data of the prostate and heart.
Authors: Nicholas Dwork, Jeremy W. Gordon, Shuyu Tang, Daniel O'Connor, Esben Sovso Szocska Hansen, Christoffer Laustsen, Peder E. Z. Larson (University of California in San Francisco, Aarhus University, University of San Francisco)